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While others have utilized droplet microfluidics-based approaches to link the heavy and light chains from a single BCR and build natively paired scFv libraries, few of these previous efforts have bioinformatically and experimentally validated the degree of native pairing 16 and the composition of antigen-specific clones within these in vivo-derived repertoires 19

Most of the real safety risk comes from unregulated, gray-market products not from properly prescribed ones

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